The Microbial Sciences group is studying the impact of the microbiome on the host immune response and its potential role in disease. We’re constantly pushing the boundaries of science to deliver life-changing medicines to patients, with a passion for discovery and a pipeline to show for it. We’re pioneering innovative research and exploring novel pathways through which the microbiome can be used across key therapeutic areas including respiratory and inflammation and cardiovascular and metabolic disease. We’re industry-leading in immunology, protein engineering and translational science. We offer a unique and collaborative network as part of the Company family, as together we explore synergies between small and large molecules.
We are seeking a cellular immunologist to characterize how the microbiome influences the immune system in respiratory, cardiovascular and metabolic diseases including COPD, asthma, heart failure and/or NASH. A successful candidate will be a critical thinker who can work in a multi-disciplinary and collaborative environment to design and implement in vitro and in vivo studies to characterize the host’s immune system. Expertise studying cellular immunology is required and knowledge of human immune cell dynamics is preferred.
- Support cellular immunology studies across therapeutic and disease areas of interest to better understand the effect of the microbiome on inflammation and immunity
- Design, execute and interpret results from animal studies to characterize host immune cell function (innate and adaptive)
- Work collaboratively with colleagues in Microbial Sciences and across the major therapeutic areas (e.g. Respiratory and Inflammation, Cardiovascular, Renal and Metabolism and Oncology) to drive projects to completion
- Prepare precise technical summaries, protocols, quantitative analyses, and maintenance of appropriate documentation
- Publish discoveries in high quality peer-reviewed journals
- Supervise associate scientists supporting projects across therapeutic and disease areas of interest and oversee the day to day organization of project-related components
Ph.D. in Immunology, Metabolism, Cell Biology, Microbiology or related field with 7+ years industry experience after post doc. Previous experience managing people in a line- or matrix-management capacity is required.
Strongly Preferred Skills:
- In depth experience with and knowledge in cellular immunology and immune cell function, as well as relevant cellular and antibody-based immunological techniques (e.g., cell-based assays, ELISA).
- Extensive experience with flow cytometry (eg multi-color panel design for cell surface staining, intracellular staining)
- Experience studying inflammatory mediators and cytokine/chemokine profiling
- Experience with animal models to study immunity and inflammation.
- Confocal microscopy or imaging experience is a plus
- Strong interpersonal skills and the ability to present complex scientific data to cross-functional and senior management teams